This research is designed for evaluation the effect of omega 3 poly unsaturated fatty acids (PUFA) on cardiovascular diseases (CVD) in rats. Thirty rats were divided into five groups each group contain six rats. The first group, control group, received control diet without any additives. The second group was injected with doxorubicin 2.5mg/kg b.wt in 6 injected equally and alternatively in 6 injections for 2 weeks. The third group was given omega 3 fish oil 400mg/kg b.wt daily for one month. The fourth group was injected with doxorubicin as second group, and then given omega 3 fatty acids for 2 weeks. The fifth group, was given fish oil omega 3 fatty acids for 2 weeks, and then was injected with dox as second group. Serum samples were collected for assessment of heart muscle function through (CK, LDH enzymes). Heart tissues were taken for histopathological examination, antioxidant enzymes activities determination, and gene expression. The result of CK and LDH concentration in serum showed significant elevation in DOX injected groups, decrease in groups received omega 3. SOD, GST and Catalase activities were elevated in groups received omega 3. GSH concentration was also elevated in groups received omega 3. The gene Rp6kb1 expression showed improvement in groups received omega 3. Finally, omega 3 have protective and therapeutic effect on cardiovascular diseases.
Key words: omega 3 fatty acids, Doxorubicin, cardiovascular diseases, cardiotoxicity
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