A series of chalcones 3-5, 1H-pyrazolines 6-8, N-phenylpyrazolines 9-11 and N-acetylpyrazolines incorporating benzofuran and pyrazole moieties were synthesized and screened for their in vitro antimicrobial activity against some of pathogenic microorganisms. Among the screened compounds 7 and 13 showed the most promising antibacterial activity against E. coil (G-). Compound 11 displayed broad spectrum antibacterial activity against B. subtilis (G+). Moreover, compounds 10 and 4 were found to be the most potent antifungal agent against C. albicans and A. niger, respectively. Also, the molecular properties prediction and drug-likeness model score of all the synthesized compounds were calculated by SwissADME and MolSoft websites, respectively. The two compounds 7 and 13 were found to be maximum drug-likeness model score of 0.75 and 0.83, respectively.
Key words: Pyrazoline, benzofuran, pyrazole, antimicrobial activities, drug-likeness, Lipinski rules
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