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Original Article

JVS. 2019; 6(1): 93-101

Cytokines profile and antibody response of calves vaccinated with conventional inactivated Trivalent FMD vaccine

Abdelaziz Abdelnasser Yassin,Ayman Hanea El Deeb,Abeer Ezzat Mansour,Hussein Aly Hussein.

In the present study, eight (sero-negative for FMDV) native breed calves (6-12 months of age) were used to study the cytokine profile including IL-2, IL-4, IFN-γ and antibody response of calves vaccinated with conventional inactivated trivalent FMD vaccine. Expression of Th1 and Th2 was determined using quantitative ELISA. Results reveled peaks of IL-4 at 7th day, IFN-γ at 14th day and IL-2 at 21st day post vaccination.
Lymphocytic proliferation assays demonstrated the continuous response of lymphocytes started at the 3rd day till reaches peak at 28th day post vaccination then start to decline. Whereas the peak titers for antibodies were reported at the 28th day post vaccination. Indeed, the study reports the role of ail adjuvant in stimulating the cellular response for inactivated vaccine.

Key words: FMD, Cytokines, MTT, VNT and cross-protection

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American Journal of Physiology, Biochemistry and Pharmacology


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