General information: Papillary thyroid cancer is the most common type of endocrine malignancy in females, and it is approximately three times more common among females than males. Given that these lesions are more common in women than men and that the rate decreases after menopause, sex steroid hormones are thought to play a role in the etiology of the benign and malignant lesions of the thyroid.
Aim: Estrogen receptor-α (ERα) and Progesterone receptor (PR) were studied in 58 patients who were diagnosed as papillary thyroid carcinoma in our hospital between 2011 and 2013. ERα and PR expression patterns were compared according to age, sex, tumor subtype, metastasis, focality, and tumor size.
Methods: ERα and PR immunohistochemical staining were performed on a Ventana Benchmark XT device. More than 10% expression of ERα and PR immunohistochemical stains in the tumor field was considered positive.
Conclusion: The findings in our study support many studies in the literature, and there is a significant relationship between tumor size, tumor stage, and metastasis and ERα and PR immunohistochemical expression. However, more studies are still needed to evaluate the effect of ERα and PR on thyroid papillary cancers.
Key words: ERα, PR, thyroid, papillary cancer, immunohistochemistry.
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