Cytotoxicity evaluation and the mode of cell death of K562 cells induced by organotin (IV) (2-methoxyethyl) methyldithiocarbamate compounds

J App Pharm Sci. 2019; 9(6): 10-15

doi: 10.7324/JAPS.2019.90602

Nurul Farahana Kamaludin,Nazifa Ismail,Normah Awang,Rapidah Mohamad,Norraphat Uttraphan Pim.

Abstract			Cited by 6 Articles
Two new organotin(IV) dithiocarbamate compounds which are diphenyltin(IV) (2-methoxyethyl) methyldithiocarbamate (compound 1) and triphenyltin(IV) (2-methoxyethyl) methyldithiocarbamate (compound 2) were tested for their toxicity against human erythroleukaemia cells (K562). The potential of both compounds to induce cytotoxicity against K562 cells was determined via MTT assay for 24 hours. The mode of K562 cells death induced by both compounds was determined by Annexin V-FITC/PI staining assay for 24 hours using the IC50 values obtained from the MTT assay for each compound. This study found that compound 1 and compound 2 were very toxic to K562 cells, producing IC50 values of less than 5.0 mg/mL ( Key words: Organotin(IV), dithiocarbamate, cytotoxicity, apoptosis, K562