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Original Article

Novel 4-hydroxy-N'-[(1E)-substituted-phenylmethylidene] benzohydrazide analogs (hydrazones) as potent antibacterial and anti-oxidant agents

Jasmine Chaudhary, Akash Jain, Rohini Manuja.

In the present study, a series of 4-hydroxy-N'-[(1E)-substituted-phenylmethylidene]benzohydrazide analogues was synthesized, characterized and evaluated for their antibacterial and anti-oxidant activity. All the tested compounds show high antibacterial activity with compound AR7, N-(3,4,5-trimethoxybenzylidene)-4-hydroxybenzohydrazide) as the most active compound whereas compound AR10 (hydrogen peroxide scavenging) and AR8 (DPPH scavenging activity method) were found to possess maximum anti-oxidant activity indicating that different mechanisms are involved in different anti-oxidant determination methods.

Key words: Synthesis, Hydrazones, Antibacterial, Antioxidant

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