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Novel 4-hydroxy-N'-[(1E)-substituted-phenylmethylidene] benzohydrazide analogs (hydrazones) as potent antibacterial and anti-oxidant agents

Jasmine Chaudhary, Akash Jain, Rohini Manuja.

Abstract
In the present study, a series of 4-hydroxy-N'-[(1E)-substituted-phenylmethylidene]benzohydrazide analogues was synthesized, characterized and evaluated for their antibacterial and anti-oxidant activity. All the tested compounds show high antibacterial activity with compound AR7, N-(3,4,5-trimethoxybenzylidene)-4-hydroxybenzohydrazide) as the most active compound whereas compound AR10 (hydrogen peroxide scavenging) and AR8 (DPPH scavenging activity method) were found to possess maximum anti-oxidant activity indicating that different mechanisms are involved in different anti-oxidant determination methods.

Key words: Synthesis, Hydrazones, Antibacterial, Antioxidant


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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
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