Objective: Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity and metabolic syndrome (MS). Liver biopsy can verify the histological form of NAFLD. The aim of the study was to evaluate the relationship between histological indicators of liver damage and metabolic parameters.
Material and methods: 80 patients, median age 45 [41.5; 47.5], with abdominal obesity and US signs of NAFLD were included in the study. All patients underwent percutaneous liver biopsy. Glucose levels during OGTT, total cholesterol, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglycerides (TG), ALT, and AST were measured. Fasting insulin, serum adiponectin, C-reactive protein (CRP) and active plasminogen antigen activator inhibitor-1 (PAI-1) were determined.
Results: NAFLD was confirmed in 77 patients (96.3%), NASH in 64 cases (80%), steatosis - in 11 cases (13.8%). In patients with steatosis, 72.7% had dyslipidemia, 63.6% had impaired glucose metabolism, 63.6% had insulin resistance (IR); with NASH in 93.8%, 78.1% and 100%, respectively. Adiponectin level correlated negatively with IR indicators: HOMA-IR (r = - 0.45; p = 0.023) and fasting insulin (r = - 0.35; p = 0.024). NASH patients had significantly higher levels of CRP than those with steatosis: 3.8 [2.1; 6.7] mg/L vs 1,1 [1.0; 1.7] mg/L, (p
Key words: nonalcoholic fatty liver disease, liver biopsy, abdominal obesity, cardiovascular risk factors, type 2 diabetes mellitus risk factors
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