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Original Research

RMJ. 2026; 51(3): 627-631


Endothelin-1 Gene Polymorphisms and their effect on endothelin-1, interleukin 6 and 18 concentrations in diabetic-hypertensive patients with coronary artery disease

Radhwan Shukur Uso, Ruqaya Muammed Gharib Al-barzinji.



Abstract
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Objective: To evaluate serum endothelin-1 (ET-1), interleukin-6 (IL-6), interleukin-18 (IL-18), and ET-1 gene polymorphism (rs5370) in CAD patients with diabetes and hypertension.
Methodology: This prospective case-control study included 100 CAD patients with DM/HTN and 100 healthy controls. Biomarkers were quantified by ELISA; rs5370 was genotyped via ARMS-PCR.
Results: CAD patients had significantly higher ET-1, IL-6, IL-18, and hsCRP (p

Key words: Coronary artery disease, endothelin-1, IL-6, IL-18, gene polymorphism, diabetes, hypertension.

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