Abstract

Objective: Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease characterized by recurrent inflammatory attacks and persistent subclinical inflammation. The role of ADAM (A Disintegrin And Metalloproteinase) family metalloproteinases in FMF pathogenesis remains unclear. This study aimed to compare serum ADAM8, ADAM10, and ADAM17 levels between FMF patients in attack-free periods and healthy controls, and to evaluate their associations with inflammatory markers.
Materials and Methods: This single-center, cross-sectional case–control study included 36 FMF patients and 36 age- and sex-comparable healthy controls. All patients were receiving regular colchicine therapy, and blood samples were collected during attack-free periods. Serum ADAM8, ADAM10, and ADAM17 levels were measured by ELISA. Acute-phase reactants [C-reactive protein (CRP), serum amyloid A (SAA), and fibrinogen] were analyzed using routine laboratory methods. Between-group comparisons, correlation analyses, multivariable binary logistic regression, and receiver operating characteristic (ROC) analyses were performed.
Results: Serum ADAM8 and ADAM10 levels were significantly higher in FMF patients than in controls (p

Key words: Familial Mediterranean Fever; ADAM8; ADAM10; ADAM17; autoinflammatory diseases; inflammation.