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RMJ. 2019; 44(3): 440-444


Hyponatremia as a predicting factor of mortality in chronic liver disease

Talha Rasheeq, Muddasar Ahmed, Muhammad Mumtaz Ather, Aamir Furqan.

Abstract
Objective: To determine the worth of hyponatremia as a predicting factor of poor prognosis and mortality in chronic liver disease.
Methodology: This retrospective cross-sectional study was carried out from January 2011 to January 2013 at Nishtar Hospital, Multan, Pakistan. All the continuous data including age, MELD score, MELD-Na score, albumin, creatinine, alanine transaminase, aspartate transaminase, gamma glutamyltransferase, total bilirubin level, serum chloride, platelet count, international normalized ratio were analyzed by applying Mann-Whitney U-test. All the nominal data were compared by Pearson Chi-square test. SPSS version 23 was used and p ≤0.05 was considered statistically significant.
Results: Serum levels of alanine and aspartate transaminases (ALT & AST), gamma glutamyltransferase (GGT), total bilirubin and international normalized ratio (INR) were significantly low in the patients with serum sodium levels of ≥139mEq/L (p=0.014,

Key words: Hyponatremia, chronic liver disease, cirrhosis.


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