Reverse Cholesterol Transport (RCT) is a mechanism critical to efflux cholesterol from macrophage to the liver for excretion into bile or feces. Impaired cholesterol efflux is one of the factors that leads to cholesterol accumulation in macrophages. Therefore, increasing cholesterol efflux may be an effective strategy for atherosclerosis prevention. ATP- binding casette transporter (ABC) A1 and G1 are key molecules in cholesterol efflux from macrophage. The objective of our study to clarify the effect of Catechins on expression of specific transporter such as ABCA1, ABCG1 form macrophage and liver SRB1 in vivo study on Wistar rats induced atherogenic diet. SRB1 is critical in facilitating the delivery of cholesterol from macrophage to the liver. The SRB1 pathway act as a receptor for large HDL particle (HDL2) and mediated the selective uptake Cholesterylester. Catechins significanly increased mRNA of ABCA1 and ABCG1 in aorta. mRNA SRB1 of liver also increase. Catechins decrease total cholesterol levels in aorta and serum. Catechins can be developed as a potential agent to increase ABCA1 to inhibit atherogenesis process. In conclusion, the study indicate that potential anti-atherogenic properties of Catechins could be explained, at least in part, as being due to upregulated expression of ABCA1, ABCG1 and SRB1 through activation LXR signaling pathway.
Key words: Catechins, Reverse Cholesterol Transport, Atherogenesis, ABCA1, ABCG1, SRB1.
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