Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



Pleiotropic effects of atorvastatin (Lipitor) on experimentally- induced hypercholesterolemic model

Nefissa Hussein Abd-ElRaheem Meky, Dina Adel Fouad, Asmaa Ahmed Mahmoud, Hoda Gamal El-Din Salem Hegazy, Marwa Hussein Ahmed Rekaby.




Abstract
Cited by 0 Articles

Atorvastatin (Lipitor) is one of the statins that have been known for their lipid-lowering effects, as well as their pleiotropic functions. The current study aimed to evaluate some pleiotropic effects of 20, 40, and 80 mg/kg b. wt of atorvastatin, orally administered to hypercholesterolemic male rats, daily for 4 weeks. The changes in body weights were tracked throughout the experiment. The study investigated serum lipid profile, atherogenic and coronary artery indices. Regarding erythrocytes membranes fluidity, erythrocytes membrane lipids and cholesterol were estimated. Regarding the antithrombotic effect of atorvastatin, complete blood count and coagulation tests including, prothrombin time and partial thromboplastin time, fibrinogen, antithrombin III, protein C, and protein S were also assessed. High-intense doses (40 and 80 mg/kg b. wt) of atorvastatin attenuated obesity, hypercholesterolemia, hypertriglyceridemia and LDL-C concentrations. Moreover, these doses of atorvastatin reduced erythrocytes membranes lipid level. Further, both doses attenuated platelets count, and increased antithrombin III and protein C, in comparison with untreated hypercholesterolemic rats. In conclusion, high-intense doses of atorvastatin exhibited anti-obesity and lipid-lowering effects. Moreover, these doses also showed pleiotropic potentials represented by improvement of the fluidity of erythrocytes membranes, reduction of coagulation and thrombosis development, which would prevent future incidence of stroke and other cardiovascular diseases.

Key words: Atorvastatin, hypercholesterolemia, erythrocytes membranes fluidity, antithrombotic effect.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.