Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

AJVS. 2017; 55(1): 60-66

The Effect of Metformin and Ginseng on Alloxan-Induced Diabetic Rats: Hematological, Biochemical and Histopathological Studies

Dina R. Gad El-Karim, Samah S. Oda, Hossam G.Tohamy, Mohamed A. Hashem.

The current study was performed to evaluate the anti-diabetic action of metformin and ginseng in alloxan-induced diabetes in rats. Forty male albino rats were used in this work, ten rats were left without any treatment and kept as a control, the remaining thirty rats were injected with alloxan to induce diabetes and then divided into three equal groups, the first group was kept without any treatment during period of the experiment, the second one treated with metformin (300 mg/kg B.Wt.) and the third one treated with ginseng at dose level of 250 mg/kg B.Wt. for 30 consecutive days. The results showed a significant changes in the hematological parameters, fasting blood glucose level, glycosylated hemoglobin (HbA1C) besides the activity of liver enzymes (aspartate aminotranseferase (AST), alanine aminotranseferase (ALT) and gamma glutamyltransferase (GGT)) and level of total protein in addition to lipid profile (Triglyceride (TG),total cholesterol (TC), very low density lipoprotein (VLDL) and low density lipoprotein (LDL) except high density lipoprotein (HDL)) in all groups compared to control group. The liver and pancreas of all groups were collected and examined histopathologically. Metformin and ginseng have ameliorative effect on biochemical and histopathological alterations caused by hyperglycemia. From our data it could be concluded that ginseng can be used as an effective anti-hyperglycemic and antioxidantagent.

Key words: Alloxan, Diabetes, Metformin, Ginseng, Rats.

Full-text options

Full-text Article

Journal of Environmental and Occupational Science


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.