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Original Article

AJVS. 2016; 51(2): 142-147

The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem.

Hyrperlipidemia refers to a metabolic disorder characterized by alterations in serum lipid and lipoprotein patterns as LDL-c , HDL-c and VLDL-c and is also identified as dyslipidemia which is associated with insulin resistance (T2DMS). Berberine is a plant alkaloid with a long history of medicinal uses in both traditional and Chinese medicine . Our study was carried out on 40 male albino rats. Hyperlipidemia was induced by feeding rats high fat diet for 8 weeks after which insulin resistance was developed as aconsequance to hyperlipidemia . Berberine chloride was after induction of hyperlipidemia for two weeks orally administration by stomach tube. Our result showed that serum lipid profile (TAG , TC , LDL-c) increased while HDL-c level was decrease moreover blood glucose level , insulin level , fructosamine level ,HbA1c level and HOMA-IR level increased at end of 8 weeks after development of hyperlipidemia . Addition of berberine chloride showed protective effect as decreased serum triglycerides , total cholesterol and LDL-c levels and increased HDL-c level more over it reduced insulin , glucose , fructosamine ,HbA1c and HOMA-IR levels.

Key words: Berberine , insulin resistance , hyperlipidemia

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