Abstract

The endothelium plays a key role in providing appropriate haemostatic balance. Endothelial progenitor cells (EPCs) are involved in the maintenance of endothelial haemostasis and in the process of forming new vessels. Cardiovascular disease (CVD) is associated with reduced numbers and dysfunction of endothelial cells (ECs) and EPCs. The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A) reductase inhibitors (atorvastatin), helps to restore of EPCs and improvement in vascular function. This review underlines the pleiotropic effects of atorvastatin on ECs and EPCs.

Key words: Endothelial cells; Endothelial Progenitor cells; Atherosclerosis; Atorvastatin