Schnitzler syndrome is an autoimmune disease characterized with chronic urticarial rashes, monoclonal gammopathy, intermittent fever, arthralgia, arthritis, bone pain, lymphadenopathy, hepatosplenomegaly, leukocytosis and elevated erythrocyte sedimentation rate (ESR). Schnitzler syndrome must be investigated in urticaria which is long acting and unresponsive to classic treatments. Lymphoproliferative disorders may accompany to Schnitzler syndrome. Although there are many kinds of treatments, response to anakinra is well. Our case was 74 years old man presented with urticarial papule and plaques on his upper part of body and proximal part of extremities. Fever, arthralgia and neutropenia were together with his lesions. Patient was used systemic steroid and antihistaminic with diagnosis of urtica. Schnitzler syndrome was diagnosed. We decided to represent this case because Schnitzler syndrome accompanied to multiple myeloma is very rare in literature and diagnosis is often delayed.
Key Words: Multiple Myeloma; Schnitzler Syndrome.
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