Aim: During general anesthesia, control of the airway is often provided with endotracheal intubation, as a result, larynx and trachea are stimulated and plasma concentrations of noradrenaline and adrenaline are increased. This increase in blood pressure and heart rate causing arrhythmias and has a negative impact on myocardial oxygen delivery and consumption. Many drugs used for the prevention response to increased sympathic activity in blood pressure and heart rate. It was aimed to evaluate the effect of dexmedetomidine versus esmolol regarding hemodynamic response to laryngoscopy and intubation on hypertensive patients during elective surgery.
Material and Methods: A total of 60 patients between the ages of 40-65 diagnosed with hypertension and receiving antihypertensive therapy were enrolled for elective surgery. Patients were randomly divided in three groups. Before standard anesthesia induction, dexmedetomidine in Group D, esmolol in Group E and serum physiologic in group K were administered.
Results: After intubation heart rate was statistically lower in Group D and Group E and higher in Group K regarding basal levels (p=0,002). Systolic arterial pressure did not change in Group E and Group K, but was statistically lower in Group D regarding basal levels (p=0,001).
Conclusions: In patients with a diagnosis of hypertension, the implementation of esmolol before induction of anesthesia is effective in preventing the hemodynamic response to laryngoscopy and intubation, but it was concluded that dexmedetomidine is more effective.
Key Words: Dexmedetomidine; Esmolol; Laryngoscopy; Hemodynamic Response.
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