To elicit whether lipid profile of hypertensive chronic uremic patients was different from those of normotensive patients, this study was performed in 14 hypertensive and 27 normotensive chronic uremic patients. Eighteen patients (9 hypertensive and 9 normotensive) were ongoing regular hemodialysis. Also 12 healthy volunteers was included to the study as control. Basal insulin levels and serum lipid profiles were determined in venous blood samples taken from the patients after 14-hour fasting. There were no any differences between hypertensive and normotensive patients in respect to mean age and body mass index. Serum triglyceride, total-cholesterol, LDL, VLDL, Apo-B, lipoprotein-(a) and insulin levels of the hypertensive patients were significantly higher than those of the normotensive ones. In dialyzed and non- dialyzed uremic patients, lipid abnormalities were not different. As a result, it was found that hypertensive chronic uremic patients had greater lipid abnormalities than normotensive patients. Therefore, it may considered that atherosclerosis will occur earlier in hypertensive chronic uremic patients. [Journal of Turgut Özal Medical Center 1997;4(3):274-278]
Key Words: Chronic renal failure, hypertension, hyperlipidemia, atherosclerosis, hyperinsulinemia
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