Objectives: The aim of rapid sequence intubation is to create fast and satisfactory intubation conditions to decrease risk of aspiration with anesthetic and muscle relaxant drugs. In our study, we compared the effects of rocuronium bromide (0.6 mg.kg-1), a fast and short effective non-depolarizing muscle relaxant with addition of alfentanyl (10 µg. kg-1) and thiopental (5 mg.kg-1) or propofol (2.5 mg.kg-1) for rapid sequence intubation on hemodynamics and intubation conditions at 60 to 90 seconds.
Material and Methods: 80 cases in ASA I-II classification undergoing elective surgery were divided into four groups. After slow administration of alfentanyl, all of the patients were preoxygenated with spontaneous breathing. The intubation had been performed at 60 s after administration of thiopental and rocuronium bromide in group I, at 90 s after administration of thiopental and rocuronium bromide in group II, at 60 s after administration of propofol and rocuronium bromide in group III and at 90 s after administration of propofol and rocuronium bromide in group IV. The patients continued to receive 100% oxygen by mask before intubation. After the administration of neuromuscular relaxant the blood pressure, heart rate, peripheral oxygen saturation at 1, 2, 5 and 15 minutes were recorded. The intubation state evaluated as excellent, good, poor and impossible, excellent and good were considered to be satisfactory. Results were compared with One-Way analysis and Chi-Square tests. p
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