Home|Journals|Articles by Year|Audio Abstracts
 

Case Report



CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA

Prithvi Varghese, Muhammed Jasim Abdul Jalal, Suhail Ahmad, Ziauddin Khan, Molly Johny, Pushpa Mahadevan, Leena Joseph, Rachel Chandy, Susy Paul.




Abstract
Cited by 6 Articles

We report a case of cerebral phaeohyphomycosis caused by a dematiaceous fungus, Fonsecaea monophora, in a patient with type 2 diabetes mellitus and decompensated chronic liver disease. CT brain revealed a 2x2cm hypodense cystic lesion in the right lentiform nucleus region with significant perilesional edema. Stereotactic burr hole aspiration of the lesion with biopsy of the abscess wall was done, and the aspirated pus from the lesion showed branched, septate hyphae with light brown pigmentation. The culture of the pus grew a dematiaceous fungus, identified by morphological and molecular studies as Fonsecaea monophora. The isolate was susceptible to voriconazole (MIC, 0.004 µg/ml) but showed reduced susceptibility to amphotericin B (MIC, four µg/ml). The patient’s caregivers were not willing for a decompressive procedure and hence was treated medically with combined Amphotericin B and voriconazole antifungal therapy. Ultimately, the patient expired due to raised intracranial tension and resultant brain-stem dysfunction. It is the first case of cerebral phaeohyphomycosis caused by Fonsecaea monophora reported from India.

Key words: Brain Abscess; Cerebral phaeohyphomycosis; Dematiaceous fungus; Fonsecaea monophora






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.