In bacterial resistance, the prompt increase against existent anti-microbial drugs is a challenging worldwide health problem. Bacteria represent a significant threat globally to healthcare associated infections, and responsible for the majority of hospital acquired infections, leading to extensive mortality and burden on global healthcare systems. In this investigation, we reported the synthesis of novel substituted phenoxy hydrazide analogs (6a-f) and have been screened for in-vitro anti-bacterial and anti-fungal activities to evaluate the zone of inhibition using paper disk agar diffusion method and a broth dilution method to determine the minimum inhibitory concentration (MIC). The structure-activity relationship (SAR) suggest that among the series (6a-f), compounds (6e) with two chloro groups and (6f) with four flouro groups showed good inhibition against pathogenic microbes. Further, these results were also confirmed by in-silico study. Based on these studies there is a scope of developing compounds (6e) and (6f) into potent anti-microbial drugs in near future.
Key words: Phenoxy hydrazide, Zone of inhibition, in-silico study.
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