Abstract

This study assessed the effect of Human Immunodeficiency Virus and Antiretroviral Drugs (ARVs) on liver enzyme markers (Aspartate aminotransferase, Alanine aminotransferase and Alkaline phosphatase) and CD4 T-cells. A total of Seventy Five (75) individuals were enrolled into the study, which comprised Twenty Five (25) HIV negative (control), Twenty Five (25) HIV positive non-treated with ARVs and Twenty Five (25) HIV positive treated with antiretroviral drugs (ARVs). Females were found to be the majority of HIV infected patients and most patients were at the middle age of 20-39 years. AST and ALT were assessed according to the Reitman and Frankel’s (1957) method, while ALP was based on King Armstrong’s (1980) method and CD4 T-cells using a method assayed of Cassens et al., (2004). The result show a significant increase (p

Key words: Aspartate aminotransferase, Alanine aminotransferase, Alkaline phosphatase, Human immunodeficiency virus and antiretroviral drugs.