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Review Article

IJMDC. 2024; 8(1): 349-353


Efficacy and safety of ibuprofen in postoperative pain management among children; systematic review

Mohammed Hassan Almuntashiri, Hamed Abdullah Alshamrani, Abdulaziz Mohammad Alqurashi, Khaled Awadh Alharthy, Abdulmjeed Awadh Almotairi, Yasir Abdul Al Aziz Al Otibi.




Abstract

Postoperative pain management is a critical aspect of care in pediatric patients undergoing surgical procedures. Ibuprofen has been examined as a treatment for mild to moderate pain in the postoperative management of children. This systematic review aimed to evaluate the efficacy and safety of ibuprofen in managing postoperative pain among children. A literature review was conducted using PubMed from 2013 to 2023. Keywords "ibuprofen," "efficacy," "safety," and "postoperative" were used for the research process. All relevant articles evaluating the efficacy and safety of ibuprofen in managing postoperative pain among children (under 18 years old) were included. The search identified 42 papers through PubMed databases. Only five studies met the objective of the systematic review. The included studies were a pooled analysis study (n=534), a prospective, double-blind, randomized clinical trial (n=30), a retrospective study (n=1065), and a multicenter, randomized, double-blind, placebo-controlled trial (n=161). Moreover, the total number of patients was 1,850, aged 1 to 19 years. Ibuprofen (oral or intravenous) and acetaminophen were the interventions examined in the included studies. The findings from the included studies suggested that ibuprofen is an effective analgesic option for children undergoing various surgical procedures. The reviewed studies consistently reported a favorable safety profile for ibuprofen in pediatric patients, with minimal incidence of adverse events. Further research with more studies is needed to expand the understanding of optimal pain management strategies in pediatric surgery and explore the comparative effectiveness of different analgesic interventions.

Key words: Ibuprofen, safety, efficacy, postoperative, pediatric surgery






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