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DNA repair gene XRCC1 and XRCC3 polymorphisms and their association with chronic myelogenous leukemia

Serap Yalcin, Meral Sarper, Gokhan Ozgur, Oral Nevruz, Ahmet Turker Cetin, Ferit Avcu.

Abstract
Objective: In the present study, because of its importance in DNA repair in cancer, we searched for polymorphisms of XRCC1 and XRCC3 genes in Turkish chronic myelogenous leukemia (CML) patients.
Methods: In order to determine these gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied using genomic DNA extracted from samples.
Results: The genotype frequencies were observed as follows: the XRCC1 Arg399Gln genotype frequencies were observed as 33.3% homozygote typical (G/G), 43.3% heterozygote (G/A) and 23.3 % homozygote atypical (A/A) in the 30 samples of patients group; the genotype frequencies of XRCC3 Thr241Met were found 50% homozygote typical (C/C), 36.7% heterozygote (C/T) and 13.3% homozygote atypical (T/T) in all samples.
Conclusion: In this study, no statistical association was found between CML and XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms in Turkish patients.

Key words: Chronic myelogenous leukemia, DNA repair genes, polymorphism, XRCC1, XRCC3


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