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Original Article

J App Pharm Sci. 2014; 4(10): 075-080


Synthesis, characterization and anticancer studies of some morpholine derived Schiff bases and their metal complexes

Nura Suleiman Gwaram, Pouya Hassandarvish.




Abstract

This paper reported series of complexes and their modes of coordination. The series consist of N,N’,O-donor Schiff base formed by condensation reaction of 2-hydroxyacetophenone with 4-(2-aminoethyl)morpholine. The ligand and complexes were characterized by elemental analysis, FT-IR, NMR and UV/Visible spectroscopy. The complexes showed moderate cytotoxicity mediated on MCF-7 breast cancer cell line and were selective to some extent when compared to the WRL68 normal liver cell line.

Key words: Schiff bases metal complexes; Anticancer; MCF-7, WRL68.






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