Objective: this study evaluated the antihyperglycemic effect of the methanol extract of Gongronema latifolium leaves singly and in combination with an oral hypoglycemic agent; glibenclamide. Materials and methods: the plant material was extracted with methanol for 48 h using cold maceration and concentrated in vacuo in a rotary evaporator. The methanol extract of G.latifolium at the doses of 200, 300, 400, 500 and 800 mg/kg were studied for antihyperglycemic effect in alloxan-induced hyperglycemic rats. More so the extract at the doses of 400 mg/kg + 5 mg/kg glibenclamide and 500 mg/kg + 5 mg/kg glibenclamide were studied for possible additive effects. Results: The 300 mg/kg of the extract decreased blood glucose at 1 h post treatment though not significantly (p>0.05) compared with 5 ml/kg distilled water, but failed to lower the blood glucose at 3 and 6 h post-treatment. The 400 and 500 mg/kg decreased the blood glucose level from 1 to 6 h post-treatment. However the decrease in blood glucose was only significant (p
Key words: G.latifolium, glibenclamide, combination, additive effect, treatment benefit
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