Abstract

Introduction: This study aims to compare the efficacy of ADCON-L and free fat graft used to prevent epidural fibrosis in the experimental laminectomy model in rabbits.
Materials and Methods: Thirty adult male New Zealand-type white rabbits weighing 2500-3000 grams were used. Three groups of ten were formed. New subjects and all subjects who replaced subjects who died during the study and follow-up period were sacrificed at the end of the 12th week. Group 1 was determined as the control group. Free fat grafts were placed into the laminectomy areas in group 2. In group 3, ADCON-L was injected into the surgical area. Subjects were sacrificed at week 12. After decalcification, laminectomy zones were taken into routine tissue follow-up for histopathological examination.
Results: When group-1 and group-3 were compared regarding fibroblastic proliferation, there was a statistically significant difference (p

Key words: Laminectomy; epidural fibrosis; free fat grafts; ADCON-L; adhesion