Community awareness and assessing the trend of suspected rabies cases play a significant role in preventing its fatality. Therefore, a cross-sectional study design was employed (October 2016 - April 2017) to assess community knowledge, attitude and practice (KAP), and Incidence and risk factors to rabies (human and animal) in the study area. A semi-structured questionnaire was employed to collect required information from 1440 study participants. Retrospective data of five-year (2012-2016) from hospitals and health centers (human cases), and veterinary clinics (animal cases) was used. Majority of the study participants (64.3%) were rural residents, 95.2% have heard about rabies and 50.1% were found dog owners. Among the study participants, 72.2%, 66.0%, and 62.4% have a good level of knowledge, attitude, and practices about rabies, respectively. A strong association between knowledge, attitude and practice with sex; educational level; occupation, dog ownership and rural/urban dwellers (p
Key words: Animal, Human, Tigray, Rabies, Status
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