Background: Interest in the physiological range of androgens in middle-aged men has recently increased since many illnesses, deaths, or male-specific disturbances are linked to androgen deficiency. It is yet unknown how dihydrotestosterone (DHT) levels have changed over time in the Indian population.
Aims and Objectives: The purpose of the study was to measure the levels of DHT in males as age. The absence of data on DHT levels in ageing males in the Indian population would allow for comparisons with future studies from other subcontinents.
Materials and Methods: In this study, residents of Moradabad, Uttar Pradesh, are the subjects of an observational and comparative case–control study.
Results: A total of 210 samples were collected, including 105 diabetic men and 105 controls, samples were divided into each of the three age brackets 30–40 years, 40–50 years, and 50–60 years. Compared to controls, who had a total mean DHT of 446.76 ± 265.31 pg/ml, diabetics’ total mean DHT was lower at 230.66 ± 182.02 pg/ml. The same was seen when diabetic samples and controls were compared by age groups. When age groups of diabetic samples and controls were compared there was no decline with the age group, there was a non-significant association in their comparison. When all of the samples were included, there was a non-significant reduction in DHT levels as the age groups progressed, although a decline was observed.
Conclusions: Age-related declines in serum DHT hormone levels occur over time but are not very significant.
Key words: Dihydrotestosterone; Androgen; Type 2 Diabetes mellitus
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