Abstract

Objective: To compare the efficacy of new pharmaceutical agent Silodosin with traditionally used agent tamsulosin”.
Methodology: From June 2020 to March 2021, a total of 120 adult patients were recruited for study. Patient’s age >18 years with confirmed distal ureteral stone were randomized for medical expulsion therapy into Group A= 60 (silodosin 8mg) and Group B=60 (tamsulosin 0.4mg). All patients received treatment for 3 weeks. They were asked to observe the stone passage in urine during treatment and follow-up with ultrasound and X ray KUB at the end of 3rd week. The primary end objective was stone expulsion. The data analysis was performed on SPSS 23.
Results: Mean age in Group A was 42.20+8.0 years and in Group B was 43.67+9.6 Years. Overall female gender was predominant (n=66 [55%]). In Group A, 34 (56.6%) patients and in Group B, 40 (66.6%) patients had right ureteral stone. The stone expulsion rate was not significantly different between two groups (p>0.05).
Conclusion: There was no statistically significant difference in stone clearance between silodosin and tamsulosin groups. Both drugs can be used for the treatment of distal ureteral stones.

Key words: Ureteral calculi, expulsive therapy, tamsulosin, Silodosin.