Objective: The impairment of antioxidant defence system and decrease of major antioxidant levels have been suggested in patients with schizophrenia. In this naturalistic follow up study, the influence of haloperidol and atypical antipsychotics on uric acid that is a potent antioxidant is aimed to compare in patients with schizophrenia or delusional disorder. Method: The data of 64 patients who were drug free at least for one week (for depot antipsychotic users, drug free at least one month) and receiving haloperidol, clozapine, olanzapine, risperidone, quetiapine or sulpiride were analyzed. No intervention was made to the treatment regimens of the patients. The plasma uric acid levels, body mass indexes of the patients were determined at the beginning and after the second month of the treatment who had complied with the treatment regimens. Results: In clozapine, olanzapine and quetiapine groups, the plasma uric acid level was found to be increased significantly after the second month of the treatment. There were no significant changes in uric acid levels among risperidone, sulpiride, haloperidol receivers two moths later. Conclusion: Regarding to our findings, atypical antipsychotics that increase uric acid level, may strengthen total antioxidant capacity and may have important function in preventing oxidative stress.
Key words: Uric acid, haloperidol, atypical antipsychotics, schizophrenia
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